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The primary enzyme responsible for metabolising nicotine is designated P450 (CYP) 2A6, and studies show genetic differences that cause variations in this enzyme from person to person - and these differences can affect the speed at which nicotine is broken down by up to half

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3 .) While the Smoking Man's place in history is fascinating on its own, it's the character's personal motivations such as writing his book, getting published, and his deep regret at not getting a true family of his own that inform this episode's tough moral: the slow-but-inevitable destruction of one's soul